CytRx Corporation (NASDAQ:CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, today announced that tamibarotene, currently under evaluation in a U.S. registration trial as a third-line treatment for acute promyelocytic leukemia (APL), showed statistically significant anti-tumor activity in human myeloma cells transplanted into animals. Multiple myeloma is an incurable malignant tumor of the plasma cells of bone marrow. Results of the trial were published in the June 2009 peer-reviewed journal Cancer Science (Volume 100, No. 6, Pages 1137-1143).

These results support our contention that tamibarotene's mechanism of action may provide broad commercial potential as a therapeutic treatment beyond APL to other cancers such as multiple myeloma, said Steven A. Kriegsman, CytRx President and CEO. Despite advances in therapies that improve the quality of life and length of survival, many multiple myeloma patients experience severe side effects from current therapies, prompting the need for additional therapies.We are evaluating opportunities for a Phase 2 clinical program with tamibarotene as a multiple myeloma therapy, as well as investigating partnership prospects for developing and commercializing tamibarotene in the U.S. for both multiple myeloma and APL, he added.

CytRx has the right to develop tamibarotene as a treatment for multiple myeloma in Europe, and has the option to expand its license for the use of tamibarotene for multiple myeloma and certain other oncology applications in the U.S. Tamibarotene is currently approved for relapsed or refractory treatment of APL in Japan.

The animal trial, conducted by an independent third party in Japan, was designed to evaluate the activity of tamibarotene as a multiple myeloma treatment alone and in combination with a glucocorticoid, a commonly prescribed treatment for this disease. Five different human myeloma cell lines were treated with tamibarotene alone, glucocorticoids alone, or tamibarotene + glucocorticoids in cell culture. Tamibarotene by itself inhibited the growth of these tumor cells two- to 10-fold more potently than all-trans retinoic acid (ATRA), a less specific relative of tamibarotene which has previously been shown to inhibit the growth of human myeloma cells. Importantly, the combination of tamibarotene with glucocorticoids was found to show markedly greater growth inhibition than either drug alone.

Human myeloma cells were then transplanted into mice with compromised immune systems to study the tumor growth-inhibitory effects of these drugs. Both tamibarotene and glucocorticoids by themselves reduced the rate of tumor growth. However, the combination of tamibarotene with glucocorticoids showed a synergistic interaction that resulted in markedly decreased tumor growth and increased survival compared with either drug alone. Trial investigators concluded that tamibarotene in this drug combination approach was among the most promising potential therapeutic regimens for multiple myeloma, especially in high-risk patients, and should be further investigated.

Our drug tamibarotene is more stable and may have fewer adverse events than ATRA, with both drugs demonstrating the ability to force certain types of leukemia cells to cease growing uncontrollably and return to performing their normal functions a process known as terminal differentiation, said Jack Barber Ph.D., CytRx's Chief Scientific Officer. Multiple myeloma cells are thought to grow uncontrollably due in part to a growth factor called IL-6. Glucocorticoids are a potent inducer of cell death; however this benefit may be offset by their known activation of IL-6 activity. Tamibarotene has previously shown the ability to interfere with the normal functioning of IL-6, which could be the foundation for the anti-proliferative effects of tamibarotene in multiple myeloma, particularly in combination with glucocorticoids.

We are delighted and encouraged by this proof of concept, which could ultimately increase the potential market for tamibarotene, added Dr. Barber.

About Multiple Myeloma

Multiple myeloma is the second most common hematologic malignancy in the U.S. According the National Cancer Institute, an estimated 20,580 new cases of multiple myeloma will be diagnosed in the U.S., and 10,580 multiple myeloma patient deaths will be recorded in 2009. According to industry leading researcher Mattson Jack Group, currently in the top seven markets (including the U.S., EU and Japan), the number of new cases each year is expected to total more than 43,500. The average five-year survival is 35 percent and the American Cancer Society found multiple myeloma to be the sixth deadliest cancer in terms of a mortality-to-incidence ratio.

Multiple myeloma is characterized by malignant plasma cells that form tumors in the bone marrow. These plasma cell tumors can spread throughout the bone marrow, thereby disrupting the production of red blood cells and platelets, which normally occur in the bone marrow. Excessive amounts of malignant plasma cells also may decrease the number of white blood cells, which are important in fighting off infections.

About Tamibarotene

Tamibarotene is an orally available, rationally designed, synthetic retinoid compound designed to potentially avoid toxic side effects by binding to its molecular target more selectively than all trans-retinoic acid (ATRA), the current first-line treatment for APL. A Special Protocol Assessment (SPA) is in place with the U.S. Food and Drug Administration (FDA) for a Phase 2 registration clinical trial, known as STAR-1, which is evaluating the efficacy and safety of tamibarotene as a third-line treatment for APL. The STAR-1 trial is ongoing and currently includes 30 clinical sites, 22 of which are in Europe, and one in Canada. CytRx believes that successful data from the STAR-1 trial and supporting studies, in conjunction with data from the Japanese clinical trials, will form the basis for a New Drug Application (NDA).

The FDA has granted Orphan Drug Designation and Fast Track Designation for the use of tamibarotene in patients with relapsed or refractory APL following treatment with all-trans retinoic acid (ATRA) and arsenic trioxide. The efficacy of orally administered tamibarotene was demonstrated in two Phase 2 studies conducted in Japan in a total of 63 Japanese subjects with APL. The overall complete response rate in these subjects was 60%. In subjects experiencing their first relapse, the overall complete response rate was 81%. In addition to multiple myeloma, CytRx also retains an option to expand its licenses for the use of tamibarotene in other fields in oncology, including myelodysplastic syndrome and certain solid tumors in the U.S., and myelodysplastic syndromes and solid tumors other than hepatocellular carcinoma in Europe.

About CytRx Corporation

CytRx Corporation is a biopharmaceutical research and development company engaged in the development of high-value human therapeutics. The CytRx drug development pipeline includes programs in clinical development for cancer indications, including tamibarotene in a registration study for the treatment of acute promyelocytic leukemia (APL). In addition, CytRx is developing two drug candidates based on its industry-leading molecular chaperone technology, which aims to repair or degrade misfolded proteins associated with disease. CytRx also maintains a 45% equity interest in publicly traded RXi Pharmaceuticals, Inc. (NASDAQ:RXII). For more information on the Company, visit www.cytrx.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. Such statements involve risks and uncertainties that could cause actual events or results to differ materially from the events or results described in the forward-looking statements, including risks relating to the timing, outcome or results of any future pre-clinical or clinical testing of tamibarotene as a treatment for multiple myeloma, risks related to CytRx's ability to manufacture its drug candidates, including tamibarotene, in commercial quantities in compliance with stringent regulatory requirements, risks related to CytRx's ability to enter into partnerships or other transactions to advance the clinical development of its portfolio of drug candidates, risks related to CytRx's need for additional capital or strategic partnerships to fund its ongoing working capital needs and development efforts, risks related to the future market value of CytRx's investment in RXi and the liquidity of that investment, and the risks and uncertainties described in the most recent annual and quarterly reports filed by CytRx with the Securities and Exchange Commission and current reports filed since the date of CytRx's most recent annual report. All forward-looking statements are based upon information available to CytRx on the date the statements are first published. CytRx undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.


Reviewed from: www.pharmalive.

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Predominant risk factors for first urinary tract infections in college-aged women
Increased sexual activity and alcohol consumption were associated with an increased risk of developing urinary tract infections (UTIs), and college-aged women experiencing urinary frequency or urgency should seek medical care to treat what may be their first urinary tract infection (UTI), according to new research presented at the 104th Annual Scientific Meeting of the American Urological Association (AUA).

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Promising findings on the in vitro and in vivo activity of microRNA-targeted therapeutics against cancer developed on the basis of its proprietary Locked Nucleic Acid (LNA) Drug Platform were announced. In both in vitro and in vivo models Santaris Pharma’s cancer targeted LNA-antimiRs demonstrated outstanding recognition and inhibition of disease-associated microRNAs due to their high specificity and affinity. The findings were presented this week at the AACR Meeting in Colorado at a symposium on microRNAs and human cancer.

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To All Members of the Brain Injury Association of Canada Community
Call to Action - Your Participation is required today
The Government has put into place a process which requires your immediate participation for passage of Bill C-289. Thanking you in advance for taking the time to advance this Bill through Parliament! Your Participation is required; this is not a done deal. If Canadians remain silent then the government could drop the legislation or stall its passage.
How to Get Involved
The Government of Canada is committed to providing the Canadian public and other stakeholders with the opportunity to participate in the development of legislative initiatives. You are invited to forward to Health Canada, detailed comments on the proposed options for legislative action regarding ski and snowboarding helmets, or any other suggestions. As applicable, please supply evidence to support your comments.
Consultation Document
This consultation is open for comment starting March 24th, 2009 until June 1st, 2009. Once you select the link for the consultation document, you will be able to read through the background and considerations, and submit your comments via email, by fax or in writing to:
Where to send it
Email: ME@hc-sc.gc.

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I was diagnosed with thyroid cancer about 3 years ago and did the surgery and radiation therapy afterwards. My thyroglobin levels are still undetectable. I have four daughters and would like to get pregnant again. We have been TTC on and off for the past year (husband was out of the country for part of it). With my daughters all I had to do was think about getting pregnant and it would basically happenthis time its just not working. My TSH levels are very supressed (.001) and Im wondering if this is my problem. Any advice.

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Tooth pain - Learn about tooth pain causes, symptoms, Tooth pain prevention and treatment, A comprehensive guide to tooth pain and toothache solutions.

Tooth pain is a common symptom, tooth pain usually refers to pain around the teeth or jaws, indicating inflammation and possible infection.

Tooth pain causes - Some of the most common causes are:
Most of tooth pain from gingivitis and periodontitis, dental caries (tooth decay) or fractured teeth and lead to the pulp (nerve teeth) caused by the infection.
tooth decay (dental caries)Tooth fracture gum disease, Infected gumsloose or broken fillingdental abscessAn exposed tooth root, Tooth Root Sensitivities.
The following problems can also cause symptoms similar to tooth pain, These include (but are not limited to):
ear infection
oral cancer
ulceration of the soft tissues can sometimes be mistaken for toothache.
Tooth pain symptoms:
There may be severe pain to pressure, or to hot or cold stimul. The pain can also get worse when you lie down because more pressure is put on the tooth.
Pain with chewing, particularly if the food or drink is hot or cold.Hot or cold sensitivityswelling around the tooth, and swelling of the jaw.

Tooth pain treatment and prevention
Self-Care at Home
1. rinsing with warm salt water
2. using dental floss to remove any food particles
3. taking aspirin or acetaminophen to relieve pain
4. using clove oil to numb the gums;
5. Avoid very cold or hot foods because this may make the pain worse.

Professional treatment
Treatment will depend on the underlying cause of the tooth pain.In most cases, dental or jaw pain can be cared for with pain medications and antibiotics.In some cases, the doctor may try an injection around the tooth for pain control. Fillings, pulling teeth, or other procedures may be performed as required.

Tooth Root Sensitivities: Flouride gel and sensitivity toothpastes that contain flouride will both help the root to become stronger and in turn reduce the toothache.

Tooth Decay: Tooth decay is the destruction of tooth enamel by dental plaque that causes holes known as cavities. In most cases, a dentist treats cavities by using a dental drill to remove the decayed material before filling the remaining space with dental amalgam or composite resin. The obvious prevention for tooth decay is to eat as little sugar. Fluoridation and dental sealants can also help prevent decay. Brush your teeth at least twice a day with a fluoride-containing toothpaste. Preferably, brush after each meal and especially before going to bed.

Gum Disease: Gum disease, including gingivitis and periodontitis. Gum disease is usually preventable. Brush twice a day for at least 3 minutes each time and floss daily. Don't smoke! Cigarettes and chewing tobacco cause mouth irritation and are very unhealthy for gums and teeth. If the bone has been destroyed, your dentist may employ a new technique called tissue regeneration, which involves grafting the bone to offer a better chance of bone re-growth.

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WASHINGTON - The use of common and readily available screening test called the ankle brachial index (ABI) could spot people with otherwise unsuspected heart risks, a new research has shown.n the study, information was analyzed from the 1999-2004 National Health and Nutrition Examination Survey (NHANES)-a nationally representative cross-sectional survey of the U.S. population for 6,292 men and women ages 40 and older without known history of heart disease, stroke, diabetes or atherosclerotic vascular disease-along with available data on standard cardiovascular risk factors and screening tests (like the ABI, which is a comparative blood pressure test).

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Improved patient-oriented investigate in aggregation module goodness dweller citizens and the dweller scrutiny business and assist the designate of technological discoveries from the work governance to the bedside. For aggregation and for the rest of the concern this try module be of enthusiastic grandness for the calibre of chronicle of individuals and the eudaemonia of gild as a whole.

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The Rise of the Fourth Reich by Jim Marrs.
Throw out everything you think you know about history. Close the approved textbooks, turn off the corporate mass media, and whatever you do, don't believe anything you hear from the government—The Rise of the Fourth Reich reveals the truth about American power. In this explosive new book, the legendary Jim Marrs, author of the underground bestseller Rule by Secrecy, reveals the frighteningly real possibility that today the United States is becoming the Fourth Reich, the continuation of an ideology thought to have been vanquished more than a half century ago.... Read more
Get The Rise of the Fourth Reich for $19.95 at Alex Jones' Infowars Store.

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Tooth pain - Learn about tooth pain causes, symptoms, Tooth pain prevention and treatment, A comprehensive guide to tooth pain and toothache solutions.

Tooth pain is a common symptom, tooth pain usually refers to pain around the teeth or jaws, indicating inflammation and possible infection.

Tooth pain causes - Some of the most common causes are:
Most of tooth pain from gingivitis and periodontitis, dental caries (tooth decay) or fractured teeth and lead to the pulp (nerve teeth) caused by the infection.
tooth decay (dental caries)Tooth fracture gum disease, Infected gumsloose or broken fillingdental abscessAn exposed tooth root, Tooth Root Sensitivities.
The following problems can also cause symptoms similar to tooth pain, These include (but are not limited to):
ear infection
oral cancer
ulceration of the soft tissues can sometimes be mistaken for toothache.
Tooth pain symptoms:
There may be severe pain to pressure, or to hot or cold stimul. The pain can also get worse when you lie down because more pressure is put on the tooth.
Pain with chewing, particularly if the food or drink is hot or cold.Hot or cold sensitivityswelling around the tooth, and swelling of the jaw.

Tooth pain treatment and prevention
Self-Care at Home
1. rinsing with warm salt water
2. using dental floss to remove any food particles
3. taking aspirin or acetaminophen to relieve pain
4. using clove oil to numb the gums;
5. Avoid very cold or hot foods because this may make the pain worse.

Professional treatment
Treatment will depend on the underlying cause of the tooth pain.In most cases, dental or jaw pain can be cared for with pain medications and antibiotics.In some cases, the doctor may try an injection around the tooth for pain control. Fillings, pulling teeth, or other procedures may be performed as required.

Tooth Root Sensitivities: Flouride gel and sensitivity toothpastes that contain flouride will both help the root to become stronger and in turn reduce the toothache.

Tooth Decay: Tooth decay is the destruction of tooth enamel by dental plaque that causes holes known as cavities. In most cases, a dentist treats cavities by using a dental drill to remove the decayed material before filling the remaining space with dental amalgam or composite resin. The obvious prevention for tooth decay is to eat as little sugar. Fluoridation and dental sealants can also help prevent decay. Brush your teeth at least twice a day with a fluoride-containing toothpaste. Preferably, brush after each meal and especially before going to bed.

Gum Disease: Gum disease, including gingivitis and periodontitis. Gum disease is usually preventable. Brush twice a day for at least 3 minutes each time and floss daily. Don't smoke! Cigarettes and chewing tobacco cause mouth irritation and are very unhealthy for gums and teeth. If the bone has been destroyed, your dentist may employ a new technique called tissue regeneration, which involves grafting the bone to offer a better chance of bone re-growth.

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MRI at 8:30am.  Get the most recent picture of the lesions.  They would treat the lesions based on these images.  I was just thankful that the 4 lesions seen on the diagnosing MRI 4+ weeks ago were still 4 lesions today.
Around 10:30am they put the head frame on and did a CT scan.  The CT scan was used for the lesions in reference to head frame (or where the head is in the scanner).  Bear in mind that they would later need to a radiation beam into ONE specific SMALL lesion in the brain (and since I have 4 lesions, I will have 4 treatments, one for each lesions).
After the CT, its just a loooong wait with the head frame on.  Supposedly the medical team was working on the treatment planning for EACH of my lesions (what angle(s) to hit the tumor from and what dosage for each angle(s) so that the tumor itself gets a maximum radiation dose but the surrounding tissues only get minimal exposure).  But of course I was not the only patient having the same procedure done, so my treatment planning was queued up waiting for others before me.
Did I mention its a loooooong day?  Good thing my brother was with me.  DB was not able to take the day off, so I was a bit uptight about it until I spoke to my brother.  Although I was allowed to eat, drink, walk around, the head frame made it impossible to take a nap, lay down, or even sit back comfortably.  I tried to eat, but the chewing motion was not comfortable.  My brother went out to get me a Hazelnut Ice Blended from Coffee Bean Tea Leaf.  That was my breakfast lunch (had to fast in the morning before the scans).  I brought a movie, so we watched a movie.  I was playing with my new cell phone, but that didnt last long since theres no phone service.
We were told that usually around 2-3pm treatment plans were getting ready so theyd start taking in patients to get treated around then.  Unfortunately, I was the last patient of the day, compliment of last minute scheduling.  Although I was scheduled for today, Jan 8th, since 2 weeks ago, I didnt have a firm schedule and I didnt have the MRI appointment until 2 days ago.  This is due to the insurance switch effective Jan 1st, for which I didnt have ANY info to tell the provider until 3 days ago.
At 3:30 I was told that Id be taken in about an hour from then.  Apparently theyre working on the patient before me.  I had been restless.  Tried to nap with all kinds of rolled up towels, blankets propped up in between the head frame.  My brother found a Sudoku game on the hospital computer and was able to get on the internet too.
I was taken in on time about 4:30.  Took about an hour, equivalent to 15 minutes for each lesions.
Left UCLA around 6pm.  Did I mention its been a looooong day?
A few other friends who had done a similar procedure before definitely had shorter days.  They all had Gamma Knife instead of the Linear Accelerator treatment that I just had.  Although I had a choice of Gamma Knife at a different hospital, I decided to go with UCLA/Linear Accelerator even though UCLA was upfront about quoting me a 10-hour day for the treatment.  My reasoning for it was the follow up MRI (all done at same facility), gathering medical records, possibly future treatmentsbasically all logistical reasons - at the expense of convenience on the day of the procedure.
There is a 3rd kind of radiosurgery (other than Gamma Knife or Linear Accelerator) that does not require wearing a head frame.  I may investigate that for future reference, in case I have to do this procedure again.
The best part about being done with the procedure is, again, the fact that the 4 lesions are still 4 lesions.  No new lesion.  And I am REALLY anxious about getting the final MRI report.  This morning, the neurosurgeons assistant said that the lesions were small (we know that), s like two millimeters Well, the smallest of my lesion was originally 3mm.  Did he say 2mm because he saw the image and guessed it was around 2mm, or did he get the actual report and it shrank from the original 3mm to 2mm?
It probably sounds anal to you, whats the difference between 3mm or 2mm, either way its tiny and either way its now been zapped by radiation and will be gone in 3 month.
It makes a huge difference for me scientifically whether the lesions were exactly the same as 4+weeks ago, or progressed, or regressed.  If the lesions were exactly the same or even regressed, that means that I POSSIBLY DIDNT NEED SRS to control the brain mets!  How?  Maybe the chemo Im on now (Doxil+Cytoxan) is able to cross the blood brain barrier after allmaybe the supplements Ive been taking (boswellia, curcumin, resveratrol, others) are able to cross the blood brain barrier or affect the tumors somehow.maybe the visualization and everything else I have done have been helpful??.

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Scientists closer to making invisibility cloak a reality
J.K. Rowling may not have realized just how close Harry Potter's invisibility cloak was to becoming a reality when she introduced it in the first book of her best-selling fictional series in 1998. Scientists, however, have made huge strides in the past few years in the rapidly developing field of cloaking. Ranked the number five breakthrough of the year by Science magazine in 2006, cloaking involves making an object invisible or undetectable to electromagnetic waves.

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So much money has been invested in cancer through charities and government organizations and still it remains a big killer.  Every year over 80,000 people are diagnosed with brain cancer.  The challenge with the brain cancer treatment comes from the fact that is located in the most delicate part of our body.  More often than not, the treatments do not work because  It is very difficult to reach so deep inside the brain to operate completely and effectively without creating any collateral damage.
A new technology is showing better promise.  In this, a fiber optic cable is inserted into the brain and guided through the maze of nerves.  The cable is not only used to see and guide its path, but also is to see the tumor and is also used to send LASER pulses.
LASER is utilized in small increments to burn/cook the tumor.  With the ability to see the area, physicians are able to control the power and duration of the LASER pulse to ensure that the heat does not damage the good cells.
Current observation as reported on ABC news is that the burning of tumor is quite effective.  The best part is that it helps you avoid Chemotherapy which is devastating.
There are other similar types of works are going on and we reported in our article Potential of Nano Technology for the Cure of Cancer.  Here we referred to another method which uses radio wave to target and burn the cells.  The story was aired on CBSs 60 minute program.
Yet, another method which has been under the development for longer period seems to be more organic and is also based on the use of nano-particles.  In this method, magnetic particiles are coated with antibodies and they are directed to the tumorous cells.  The expectation is that these antibodies will bond with the cancerous cells to change their characteristics.  Dr. Archana Dubey of the Physics Department at University of Central Florida did significant amout of work on the coating of nano particles and theri characterization.  She is currently modeling the molecular bevahiour of haemoglobin which could lead to development of applications for diagnostics and cure of blood cancer.  What this does is the localization of cure and because it is organic, the expecation is that there will be little chance of side effects or of tumor growing back.

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It’s already been noted that Barack Obama’s election seems to have had a positive affect on the educational achievements of African-American students. This affect stems in part from what social psychologists call self-image or self-expectation theory. The idea is that a lot of what we do is motivated by the kind of person we want to be, the kind of social groups we take ourselves to belong to, and the kind of person others think we are.
 
People will often not do something if it doesn’t chime with their values, or if they feel they will be judged to have behaved badly by people they respect, admire or simply identify with. They will try to make their actions cohere with a self-image and social identity that they project ahead of them.
 
Or conversely, if people find themselves doing something regularly, they will adjust their values to their behaviour in order to maintain coherence: if I find myself regularly reading trashy magazines, I may well adjust my prior attitude that reading them is a waste of my time. But when I make this adjustment it must fit with the overall coherence of my values and attitudes: I tell myself reading trashy magazines is an acceptable form of relaxation for a busy person like me, as long as it doesn’t take up too much time.
 
So we will often mimic others we take to share our values and attitudes. But we will also mimic those we take to be adept at adjusting their attitudes and values to their actual behaviour – we will trust them more because there is no dissonance between what they say and do. In short, we find a combination of a shared orientation on the world and personal integrity highly inspiring.
 
What is inspiring about Barack Obama so far is his presentation of himself as an intelligent, empathic, balanced, determined, elegant, patient, calm, virtuous person. But he has also shown himself to be skilled at adjusting his values and attitudes to the behaviour these uncertain times have forced upon him. He has tempered his ‘can-do’ self-confidence with the humility that austerity brings. But he hasn’t simply jettisoned the former – rather, just seen when and where it is appropriate. And he has found the words to express this adjustment in a way that the public can identify with.
 
I think it is important for leaders to possess this ability. For then we, the public, will identify with the image they project, and adopt it as our own. They can provide a lead on maintaining certain values and attitudes in uncharted waters, and, conversely, on what adjustments in those values and attitudes are required by the times. If they are successful, we internalise the image they project which helps us to motivate ourselves to change our behaviour for the better. In present times that means, for example, feeling good about saving more money, being more energy efficient, being more concerned for others around us. And one should never underestimate the power of such motivation.
 
But if Obama’s words become too dissonant with his behaviour, or vice versa, we will lose trust in him. So we are as much influencing him as he us.
 
Gordon Brown showed himself to capture the spirit of the times for a brief moment. But he seems to be a one-trick pony. Thus politics in the media age is not as anti-democratic as we might think: his apparent inability to adjust his behaviour to maintain his values and attitudes in uncertain times, as well as his apparent inability to adjust his values and attitudes to match behaviour that was forced upon him; all this causes a cognitive dissonance it seems many find uninspiring.

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Through the years there have been a number of studies conducted to determine the connection between prostate cancer and alcohol. One such study was done at Fred Hutchinson Cancer Research Center which is located in Seattle. In this test 1,456 men answered a dietary questionnaire that was detailed in nature and they underwent a personal evaluation. These men were between the ages of forty and sixty-four years old.

The scientists collected all the information they could that would even slightly influence the risk of getting this type of cancer. Information included age, height, weight, race, family history, occupation, lifestyle, sexual history, caloric intake and even marital status. Their complete medical history was reviewed and then a detailed account of their alcohol consumption was assessed.

What Was Found In the Study?
In this study the scientists went a step further than they have with other studies by separating the different types of alcohol that were consumed. Data revealed that men who consumed more than thirty-five beers a week for about eight years or more actually increased their risk of cancer of the prostate. However, men who drank wine reduced their risk.

Further studies showed that red wine was contributed the most benefits for reducing risk factors. In fact, it was determined that men who consumed somewhere between four and seven glasses of red wine could reduce their risk of prostate cancer by as much as fifty-two percent. Red wine also appeared to help protect against other aggressive or advanced types of cancers.

Why Does Red Wine Reduce Your Risk?
Why does red wine make such a difference? The truth is that no one really knows, but there are some theories.

For instance, red wine contains flavonoids and resveratrol, which both contain antioxidant properties. It appears that some of these properties counterbalance androgens, which are the hormones that stimulate the prostate glands. Tests show that resveratrol can induce apoptosis which is a process that kills the prostate cancer cells. The flavonoids seem to reduce the PSA production of prostate cancer cells, which actually suggest that a decrease in cellular activity is taking place.

Very seldom will a doctor recommend that you drink alcohol to enhance your health and for good reason. Many people could use this as an excuse to become an alcoholic and excessive alcohol use could cause other serious medical conditions.

It's also important to remember that this was just one study and more need to be conducted so results can be compared. Considering the results of this study, however, it's probably reasonable to assume that a favorable link between red wine and prostate cancer will be confirmed in the future.

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London, January 1 (ANI): Scientists at the University of California, San Diego School of Medicine claim that they have identified a protein produced that enhances the spread of lung cancer by stimulating the activity of inflammatory cells.
The researchers said that their work may be helpful in gaining a deeper understanding as to how advanced cancer cells usurp components of the host innate immune system to generate an inflammatory microenvironment hospitable for the metastatic spread of lung cancer.
That, in turn, could result in a therapy to limit metastasis of lung cancer, added the researchers.
Lead researcher Michael Karin, UC San Diego Distinguished Professor of Pharmacology and Pathology, said that his team used a straightforward biochemical approach to identify proteins produced by metastatic cancer cells, which are responsible for generation of an inflammatory microenvironment that supports the growth of metastases.
He said that the team focused on macrophages, white blood cells that are key players in the immune response to foreign invaders as well as in cancer growth and progression, and screened for factors produced by metastatic cancer cells in mice that could stimulate the activity of this inflammatory cell type.
He said that the study revealed that a highly metastatic cell line called Lewis lung carcinoma (LLC) showed particularly potent activation of macrophages.
Karin further said that macrophage activation was mediated by a secreted protein.
The researchers said that biochemical purification of proteins secreted by LLC cells resulted in identification of an extracellular matrix protein called versican as the major macrophage activator and metastasis enhancing factor.
They found that versican strongly enhances LLC metastatic growth by activating receptors that lead to production of cytokines - signaling proteins that regulate the immune system. One of those receptors, TLR2, and a cytokine, TNFa, were found to be required for LLC metastasis.
However, the normal function of TLR2 and TNFa is in host defence-innate immunity to microbial infections.
Karin said that his team #39s findings were relevant, not just to the mouse model, but also to human lung cancer - the most common cause of cancer-related deaths worldwide.
By usurping these elements of the host immune system, versican helps generate an inflammatory environment that spurs the growth and spread of metastatic cancer. If we can find a way to block the production of versican or its binding to TLR2, therapeutic intervention could be used to limit metastasis of lung cancer, Nature magazine quoted him as saying.

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yellowsn0w has officially been released by the iPhone Dev Team. Now you can unlock your iPhone 3G(even if you used quickpwn to activate and jailbreak it) and its really easy to setup.
All you have to do is go into Cydia(or Installer) and search for it. I just go to the tab and look for the most recent updates(which shows yellowsn0w right at the top).
If you dont see it then you probably dont have the correct sources installed. Which are. . .
* Cydia source: http://apt9.yellowsn0w.com/
* Installer repo: http://i.yellowsn0w.com/
You should just be able to install it and then youre done. But some are having issues(like with t-mobile where you have to turn 3G off for it to work). If youre having any odd errors like that then the iPhone Dev Team has some information that will help you.

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I would love to be un-aware for just one day, please!

Ever since I was diagnosed with cancer, my ears now perk up whenever I hear or see anything about the subject and this reminds me about my own health and it makes me sad. Enough encounters with these demonic reminders and I go into a depression. I would love to go one whole day without someone or something reminding me of my cancer.

It's bad enough that I am reminded every time I get dressed, take a shower, or apply Mederma to the scars. I also see one of my 3 doctors quarterly and have to get mammo's and MRI's just as often. That's enough reminding for me.

Imagine, if you can, people popping out of bushes or from behind corners shouting "You have cancer!" several times a day, every day. That's what it's like! I wish I could shut these annoying people up. (I know they mean well...)

Here are some examples of what my overexposure to breast cancer awareness is like:

Last year a friend made a donation to the Susan G. Komen fund in my name. SGK sent me a little card. It was a nice gesture by my friend but I really didn't need SGK to tell me.

After I was diagnosed, I received multiple visits from Teleflora and 1-800-Flowers. My surgeries coincided with the month of my birthday so I also received flowers from my brother-in-law who didn't know yet. I treasured this bouquet because these were not pity flowers.

This year two friends went on fundraiser walks/marathons and asked me to join them. I wasn't emotionally strong enough for this. I needed to distance myself.

The last time I replaced my latex dishwashing gloves my only choice was pink "breast cancer awareness" gloves from Playtex.

This past summer I buried a friend who died from breast cancer. She had been my "big sister" who held my hand and answered my questions when I "joined the club." She handed down her scarves to me, not knowing that a year later her own cancer would return. I was an emotional wreck at the funeral. I felt like Scrooge did when he met up with the Ghost of Christmas Future at the cemetary. Someone saw me loosing it and rescued me into her hug.

Every once in awhile I receive phone calls asking me to donate money to find a cure. I tell them I donated almost $3000 last year and this year looks like it's going to be about $1000.

The entire month of October the grocery store I shop at had a huge display of pink stuff for sale - scarves, mittens, vacuum cleaners, cupcakes, cakes, ice scrapers... I recently visited Linens'n'Things to take advantage of their going-out-of-business sale - there was a big display of pink MMs and Tic Tacs at the entry. I think I've developed an adversion to things pink.

I used to have long hair- half way down to my elbows. Maybe once or twice a month I'll run into someone I haven't seen in awhile and they always comment on why on earth did I cut my hair. Do I tell them the truth or lie?

At the cash register area of the local arts crafts store last week, there was a huge display of silk flowers and grave markers - giant pink ribbon symbols. This little event just screamed DEATH as well as Breast Cancer to me.

I hear about breast cancer on tv, on the radio, on the internet, on magazine covers...it's everywhere and I am feeling a little too exposed to it. Yes, I am very aware, so let's please change the subject and talk about something else.

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December 22, 2008
Researchers have made several, subtle changes in the structure of a key protein, dramatically increasing its ability to drive blood clotting, according to a study published in a December edition of the Journal of Thrombosis and Haemostasis. The findings have profound implications for the treatment of hemophilia, the inherited blood disorder that causes easy or excessive bleeding in 30,000 Americans.

Similar posts: brain cancer

You cannot walk down the street, drive in your car or wait on line at the unemployment office today without seeing dozens of people glued to their cell phones. When did this happen?  How did we become a people that must maintain uninterrupted contact with every person we’ve ever met during all of our waking hours?  Even worse, no matter what kind of plan you sign up for -  Friends, Family, Free Texting, Free Weekends, Free Nights, Free Phone with 1000 Minutes, Free 1000 Minutes with Phone - somehow or other the bill is always upwards of $100.  That’s one hundred bucks a month to hear about how your wife is mad at her mother again or your brother shot a forty on the back nine, information that certainly could wait until the next time you see each other or maybe never. That is only one reason among many that we are suggesting the following radical approach to saving money on your cell phone bill, or even better, eliminating it completely: 
Go Amish. 
The Amish Church, as you certainly remember from Comparative Religion or the movie,Witness, isn’t into modern technology.  They don’t drive cars, they don’t watch TV, four families raising a barn is their idea of swinging.  Most importantly, they don’t use cell phones.  Which means they don’t have to pay for them.  And neither will you, once you sign up with them.
Of course, we’re not suggesting that you go live on a…whatever you call it, where Amish people live.  This blog is dedicated to practical, working solutions to our current stinkbomb of an economy and uprooting your entire lifestyle to save a hundred bucks a month does not meet that standard.  If you did want to move in with the Amish, however, that would be your decision and should you then regret that decision and want to leave and they tried to keep one of your children or made you take one of their children, or have sex with their elders, or youngers, we would be absolved from any responsibility whatsoever, now and for perpetuity.
(Please forgive the above legal mumbo-jumbo.  Our team of crack paralegals scrupulously reviews all our blogs in order to protect us from the frivolous lawsuits that are sure to follow our nation-sweeping popularity.)
Back to the point in question (or is it the question in point, we can never remember), should people ever question why you don’t have a cell phone anymore, all you have to say is, “My religion doesn’t allow it.”  For most people that will be explanation enough.  In fact they will immediately change the subject or rush off to converse with someone who is not a religious zealot.  For those who instantly comprehend the reasoning behind this technique and reply that, funny you should mention it because they too have been thinking about tossing their bonnet into the ring with the Amish and do you happen to know where they can sign up, embrace them warmly, for you have found a fellow believer.
Bottom line: The Verizon Amish Plan, $0 a month and $0 annually.

Similar posts: brain cancer